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JHU 37160
CAS No. 2369979-68-8
JHU 37160 ( —— )
Catalog No. M24085 CAS No. 2369979-68-8
JHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 38 | In Stock |
|
| 25MG | 70 | In Stock |
|
| 50MG | 113 | In Stock |
|
| 100MG | 177 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJHU 37160
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NoteResearch use only, not for human use.
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Brief DescriptionJHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively.
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DescriptionJHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetAChR
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RecptorM3 mAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number2369979-68-8
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Formula Weight358.9
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Molecular FormulaC19H20ClFN4
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Purity>98% (HPLC)
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SolubilityDMSO:72 mg/mL (200.65 mM);Ethanol:72 mg/mL (200.65 mM)
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SMILESFC1=C2NC3=CC=C(Cl)C=C3N=C(N4CCN(CC)CC4)C2=CC=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bonaventura J , Eldridge M , Hu F , et al. High-potency ligands for DREADD imaging and activation in rodents and monkeys[J]. Nature Communications, 2019, 10(1).
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